Her father, Louis XI., who had hoped for a son to succeed him, banished Jane from his palace, and, it is said, even attempted her life. At the age of five the neglected child offered her whole heart to God, and yearned to do some special service in honor of His blessed Mother. At the king's wish, though against her own inclination, she was married to the Duke of Orleans. Towards an indifferent and unworthy husband her conduct was ever most patient and dutiful. Her prayers and tears saved him from a traitor's death and shortened the captivity which his rebellion had merited. Still nothing could win a heart which was already given to another. When her husband ascended the throne as Louis XII., his first act was to repudiate by false representations one who through twenty-two years of cruel neglect had been his true and loyal wife. At the final sentence of separation, the saintly queen exclaimed, "God be praised Who has allowed this, that I may serve Him better . than I have heretofore done." Retiring to Bourges, she there realized her long-formed desire of founding the Order of the Annunciation, in honor of the Mother of God.

Under the guidance of St. Francis of Paula, the director of her childhood, St. Jane was enabled to overcome the serious obstacles which even good people raised against the foundation of her new Order. In 1501 the rule of the Annunciation was finally approved by Alexander VI. The chief aim of the institute was to imitate the ten virtues practised by Our Lady in the mystery of the Incarnation, the superioress being called "Ancelle," handmaid, in honor of Mary's humility. St. Jane built and endowed the first convent of the Order in 1502. She died in heroic sanctity, 1505, and was buried in the royal crown and purple, beneath which lay the habit of her Order.